Endocrine Abstracts

Background: Lead is known as an environmental toxic pollutant and hormonal regulatory confounder associated with obesity. Recent China scientific report shows that blood lead level (BLL) is closely related with body mass index. Therefore, we investigated the association between the prevalence of metabolic syndrome and blood lead levels in healthy general population without hypertension, dyslipidemia, and diabetes.Methods: We assessed the socio-demographi...

A 68 year old gentleman referred to endocrinology clinic with a few years history of erectile dysfunction (ED), which manifested as reduced libido and partial erections. Investigations revealed primary hypogonadism with a low morning serum Testosterone of 4.8 (Ref: 7.9-31 nmol/l), raised FSH at 47 (Ref:1.5-12.4 iu/l) LH at 36.8 (Ref: 1.7-8.6iu/l) and normal thyroid function tests (TFTs). The patient declined testosterone replacement therapy following a discussion of pros and c...

Hypogonadotropic hypogonadism (HH) is a rare reproductive disorder that results in a lack of normal pubertal development and reduced potential for fertility in adult life. The condition is characterised by low circulating sex steroid concentrations resulting from a deficiency of pituitary gonadotropin production. HH may be congenital or acquired, most commonly due to tumour or treatment for malignant disease. When associated with anosmia it is termed Kallmann syndrome. HH is a...

Background: Bilateral cataracts are rarely the initial symptom of diabetes mellitus (DM). Patients with DM who developed cataracts usually have DM for many years. The prevalence of early cataracts in paediatric DM ranges between 0.7 and 3.4%. We report a case of DM diagnosis following onset of blindness due to new bilateral cataracts.Case description: 13-year-old Caucasian girl presented with rapidly declining vision for 2 months. She was blind 2 weeks p...

Introduction: Childhood papillary thyroid carcinoma (CPTC), despite bilateral thyroidectomy (BT), nodal resection and radioiodine remnant ablation (RRA), recurs within neck nodal metastases (NNM) in >30% within 20 postoperative years. However, these NNM are usually treated with re-operation or further radioiodine; US-guided ethanol ablation (EA) may be considered (j.sempedsurg.2020.150920) for patients with limited numbers of NNMMethods: We studied l...

Background: Neuroendocrine tumor (NET) metastases to the heart are found in 1-4% of NET patients and have been reported primarily in the form of individual cases. We investigated the incidence, clinical characteristics, imaging features, and outcomes of NET patients with cardiac metastases on 68Ga-DOTATATE PET/CT.Methods: The medical records of 406 neuroendocrine tumor patients who underwent 68Ga-DOTATATE PET/CT for their clinical c...

Objectives: This prospective study aimed at investigating (1) the prevalence of vitamin D deficiency and insufficiency in diabetic adolescents and children in a multi-ethnic cohort, and (2) any association between vitamin D status and ethnic background, glycaemic control (HbA1C), biomarkers of metabolic bone health and lipids.Methodology: Venous blood was drawn from 199 patients with type 1 diabetes (mean age ± SD, 8.2 ± 3.7 years) and 48 patients ...

Introduction: Sodium Glucose Co-transporter 2 inhibitors (SGLT2i) are a novel class of glucose-lowering therapies that have demonstrated prognostic benefit in the management diabetes, heart failure and renal impairment. National Institute for Health and Clinical Excellence (NICE) guidance recommends offering SGLT2i, in addition to metformin, first-line in individuals with type 2 diabetes (T2D) and chronic heart failure/ established atherosclerotic cardiovascular disease. Howev...

Introduction: 2 to 3% of the causes of hypoglycemia in the population without diabetes mellitus correspond to tumors of cells other than islets. Below is a rare case of hypoglycemia related to a pleural tumor. Clinical case: A 65-year-old woman with arterial hypertension, psychiatric treatment for confusion and behavioral changes of 6 months of evolution, palpitations and night sweats, loss of 20 kg of weight, several admissions to the emergency room, un...

Objective: Non-alcoholic fatty liver disease (NAFLD) is considered as a continuum from obesity and metabolic syndrome (MetS). To investigate the cardiovascular prognosis of metabolically healthy NAFLD, this study aimed to evaluate the association between NAFLD with and without MetS and change in coronary artery calcification (CAC).Methods: This is a retrospective longitudinal study of 5,117 subjects without cardiovascular disease who participated in a he...